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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Syvn1tm1Tn
targeted mutation 1, Toshihiro Nakajima
MGI:2679656
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Syvn1tm1Tn/Syvn1tm1Tn D1.Cg-Syvn1tm1Tn MGI:2679657
ht2
 		Syvn1tm1Tn/Syvn1+ D1.Cg-Syvn1tm1Tn MGI:2679674


Genotype
MGI:2679657
hm1
Allelic
Composition		 Syvn1tm1Tn/Syvn1tm1Tn
Genetic
Background		 D1.Cg-Syvn1tm1Tn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syvn1tm1Tn mutation (0 available); any Syvn1 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:86009 )
• mice die in utero exhibiting abnormal apoptosis systemically

cellular
abnormal apoptosis ( J:86009 )
• systemic aberrant apoptosis




Genotype
MGI:2679674
ht2
Allelic
Composition		 Syvn1tm1Tn/Syvn1+
Genetic
Background		 D1.Cg-Syvn1tm1Tn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syvn1tm1Tn mutation (0 available); any Syvn1 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased apoptosis ( J:86009 )
• enhanced apoptosis of synovial cells

immune system
decreased susceptibility to induced arthritis ( J:86009 )
• resistance to collagen-induced arthritis due to enhanced apoptosis of synovial cells

skeleton
decreased susceptibility to induced arthritis ( J:86009 )
• resistance to collagen-induced arthritis due to enhanced apoptosis of synovial cells
abnormal joint morphology ( J:86009 )
• enhanced apoptosis of synovial cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory