Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Prkcatm1Far
Name:	protein kinase C, alpha; targeted mutation 1, Bob Farese
MGI ID:	MGI:2679305
Synonyms:	PKCalpha-
Gene:	Prkca  Location: Chr11:107824213-108234754 bp, - strand  Genetic Position: Chr11, 70.8 cM
Alliance:	Prkcatm1Far page

Germline Transmission:	Earliest citation of germline transmission: J:85923
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 2 was replaced with a neomycin selection cassette via homolgous recombination. Normal transcript was undetected by RT-PCR analysis RNA obtained from the brain tissue of homozygous mutant mice. (J:85923)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

List all tumor models in MMHCdb carrying Prkcatm1Far

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prkca Mutation:	43 strains or lines available

Original:	J:85923 Leitges M, et al., Knockout of PKC alpha enhances insulin signaling through PI3K. Mol Endocrinol. 2002 Apr;16(4):847-58
All:	40 reference(s)