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Birc6Gt(pT1Betageo)45Flo
Gene trapped Allele Detail
Summary
Symbol: Birc6Gt(pT1Betageo)45Flo
Name: baculoviral IAP repeat-containing 6; gene trap 45, Thomas Floss
MGI ID: MGI:2678436
Synonyms: Birc6Gt(pT1Betageo)1Ruiz, Bruce
Gene: Birc6  Location: Chr17:74835290-75010351 bp, + strand  Genetic Position: Chr17, 45.64 cM, cytoband E3
Alliance: Birc6Gt(pT1Betageo)45Flo page
Mutation
origin
Mutant Cell Line:  W036C08
Germline Transmission:  Earliest citation of germline transmission: J:85162
Parent Cell Line:  TBV2 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector: pT1betageo
 
Mutation detailsThe endogenous locus was disrupted by the insertion of a gene trap vector containing a splice acceptor site followed by Beta-geo and a polyadenylation signal. (J:85162, J:99584)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Birc6 Mutation:  240 strains or lines available
Notes
GGTC records currently say that TBV2 ES cells were used to generate this allele. However information submitted to the NCBI Genome Survey Sequences Database (dbGSS) by the German Genetrap Consortium (GGTC) for gene trap cell line W036C08 gives R1 as the ES cell line used to create this allele. The original publication reporting large scale production of gene trap clones using four gene trap vectors says that ES cell-derived chimeras were produced using three ES cell lines (E14.1 (129P2/OlaHsd), R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl+), TBV2 (129S2/SvPas)). Chimeric mice were subsquently bred to C57BL/6 females.
References
Original:  J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory