Summary | Transgene origin | Transgene description | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Tg(Cga-LHB/CGB)94Jhn
Name:	transgene insertion 94, John H Nilson
MGI ID:	MGI:2446075
Synonyms:	LHbetaCTP, LHbeta-CTP, LH-CTP, Tg(bLHbeta-CTP)94Jhn, Tg-LHbeta
Transgene:	Tg(Cga-LHB/CGB)94Jhn  Location: unknown
Alliance:	Tg(Cga-LHB/CGB)94Jhn page

Strain of Origin:

(C57BL/6 x SJL)F1

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Cga-LHB/CGB)94Jhn expresses 1 gene Transgene expresses: Organism Expressed Gene Note cattle LHB (280839)   Mutation details: The transgene contains the entire bovine luteinizing hormone beta (LHB) cDNA fused to 87 bp encoding the c-terminal peptide (CTP) of the human chorionic gonadotropin beta subunit (CGB). The bovine glycoprotein hormone alpha subunit (CGA) promoter (positions -315 to +45) was used to drive expression in gonadotropes. Immunohistochemical analysis confirmed both LHB and CTP expression in the pituitaries. (J:55157)

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Tg(Cga-LHB/CGB)94Jhn

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:55157 Risma KA, et al., Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors. Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1322-6
All:	23 reference(s)