Analysis Tools
reproductive system
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• luteal cells have a prolonged lifespan, with pseudopregnant female mice having elevated progesterone levels for 18 days compared to less than 12 days for littermate controls
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• some of the females have enlarged ovaries that are packed with corpora lutea
• progesterone levels are elevated in these mice
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ovary cyst
(
J:55157
)
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• some mice have numerous cysts in their ovaries that are hemorrhagic or fluid filled and derived from both follicular and luteal tissue
• cystic ovaries have increased blood flow to the tissue
• testosterone and estradiol levels are elevated in these mice
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small testis
(
J:55157
)
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• testes in transgenic males is significantly smaller than in controls
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• a subset of transgenic females develop ovarian granulose and theca-interstitial cell tumors by 4-8 months of age
• these tumors contain varying amounts of other stromal cells and have an increased blood supply
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• some males breed after prolonged delays
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anovulation
(
J:55157
)
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• 12-16 week old female mice fail to ovulate
• female mice fail to ovulate even when ovulation is tried to be forced through pseudopregnancy
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• only 1 female of 9 that mated multiple times was able to produce a litter
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• male mice have reduced fertility with some males never breeding and others breeding after prolonged delays
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neoplasm
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• a subset of transgenic females develop ovarian granulose and theca-interstitial cell tumors by 4-8 months of age
• these tumors contain varying amounts of other stromal cells and have an increased blood supply
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renal/urinary system
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• in some mice the hydronephropathy is complicated by acute pyelonephritis
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• some mice develop chronic interstitial nephritis
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• about 25% of infertile females have hydronephrosis of the kidneys
• in some mice the hydronephropathy is complicated by acute pyelonephritis whereas others have chronic interstitial nephritis
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• about 25% of infertile females have dilated ureters associated with hydronephrosis of the kidneys
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• about 25% of infertile females have enlarged bladders associated with hydronephrosis of the kidneys
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homeostasis/metabolism
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• serum LH levels for female mice are elevated at 39.7 ng/ml compared to 2.7 ng/ml for littermate controls
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• transgenic females that have enlarged ovaries also have vastly elevated progesterone levels
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endocrine/exocrine glands
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• luteal cells have a prolonged lifespan, with pseudopregnant female mice having elevated progesterone levels for 18 days compared to less than 12 days for littermate controls
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• cells expressing markers of gonadal origin reside in the subcapsular zone of the adrenal cortex where stem cells normally reside
• these cells express high levels of phosphorylated Smad3
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• some of the females have enlarged ovaries that are packed with corpora lutea
• progesterone levels are elevated in these mice
|
ovary cyst
(
J:55157
)
|
|
• some mice have numerous cysts in their ovaries that are hemorrhagic or fluid filled and derived from both follicular and luteal tissue
• cystic ovaries have increased blood flow to the tissue
• testosterone and estradiol levels are elevated in these mice
|
small testis
(
J:55157
)
|
|
• testes in transgenic males is significantly smaller than in controls
|
|
|
• a subset of transgenic females develop ovarian granulose and theca-interstitial cell tumors by 4-8 months of age
• these tumors contain varying amounts of other stromal cells and have an increased blood supply
|
immune system
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• in some mice the hydronephropathy is complicated by acute pyelonephritis
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• some mice develop chronic interstitial nephritis
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cellular
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• luteal cells have a prolonged lifespan, with pseudopregnant female mice having elevated progesterone levels for 18 days compared to less than 12 days for littermate controls
|
growth/size/body
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|
• some of the females have enlarged ovaries that are packed with corpora lutea
• progesterone levels are elevated in these mice
|
ovary cyst
(
J:55157
)
|
|
• some mice have numerous cysts in their ovaries that are hemorrhagic or fluid filled and derived from both follicular and luteal tissue
• cystic ovaries have increased blood flow to the tissue
• testosterone and estradiol levels are elevated in these mice
|
