Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Trim25tm1Mura
Name:	tripartite motif-containing 25; targeted mutation 1, Masami Muramatsu
MGI ID:	MGI:2673138
Synonyms:	efp -/-
Gene:	Trim25  Location: Chr11:88890202-88911119 bp, + strand  Genetic Position: Chr11, 54.34 cM, cytoband C
Alliance:	Trim25tm1Mura page

Germline Transmission:	Earliest citation of germline transmission: J:77296
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced a genomic segment containing exon1, which encodes the translation start site and RING finger domain. Northern blot analysis demonstrated that no detectable transcript was present in uteri of homozygous mice. Western blot analysis of proteins derived from uteri of homozygous mice confirmed that no detectable protein product was made. (J:77296)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trim25 Mutation:	41 strains or lines available

Original:	J:77296 Orimo A, et al., Underdeveloped uterus and reduced estrogen responsiveness in mice with disruption of the estrogen-responsive finger protein gene, which is a direct target of estrogen receptor alpha. Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):12027-32
All:	4 reference(s)