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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trim25tm1Mura
targeted mutation 1, Masami Muramatsu
MGI:2673138
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trim25tm1Mura/Trim25tm1Mura involves: 129S4/SvJae MGI:6149724
hm2
 		Trim25tm1Mura/Trim25tm1Mura involves: 129/Sv * 129S4/SvJae MGI:2673142
cx3
 		Trim25tm1Mura/Trim25+
Usp15L749R/Usp15+ 		involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J MGI:6149725


Genotype
MGI:6149724
hm1
Allelic
Composition		 Trim25tm1Mura/Trim25tm1Mura
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trim25tm1Mura mutation (1 available); any Trim25 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to parasitic infection induced morbidity/mortality ( J:259382 )
• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are resistant to fatal encephalitis independent of blood-stage replication unlike wild-type mice

immune system
decreased susceptibility to parasitic infection ( J:259382 )
• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are resistant to fatal encephalitis independent of blood-stage replication unlike wild-type mice
decreased susceptibility to parasitic infection induced morbidity/mortality ( J:259382 )
• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are resistant to fatal encephalitis independent of blood-stage replication unlike wild-type mice




Genotype
MGI:2673142
hm2
Allelic
Composition		 Trim25tm1Mura/Trim25tm1Mura
Genetic
Background		 involves: 129/Sv * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trim25tm1Mura mutation (1 available); any Trim25 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
small uterus ( J:77296 )
• underdeveloped when studied in the secretory phase of the cycle
• unresponsive to estrogen-induced uterine growth after ovariectomy




Genotype
MGI:6149725
cx3
Allelic
Composition		 Trim25tm1Mura/Trim25+
Usp15L749R/Usp15+
Genetic
Background		 involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trim25tm1Mura mutation (1 available); any Trim25 mutation (41 available)
Usp15L749R mutation (0 available); any Usp15 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to parasitic infection induced morbidity/mortality ( J:259382 )
• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are increased partially (60% survival) resistant to fatal encephalitis compared with single heterozygotes (20-30% survival)

immune system
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:259382 )
• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are increased partially (60% survival) resistant to fatal encephalitis compared with single heterozygotes (20-30% survival)
decreased susceptibility to parasitic infection induced morbidity/mortality ( J:259382 )
• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are increased partially (60% survival) resistant to fatal encephalitis compared with single heterozygotes (20-30% survival)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory