Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rrm2btm1Ynak
Name:	ribonucleotide reductase M2 B (TP53 inducible); targeted mutation 1, Yusuke Nakamura
MGI ID:	MGI:2672883
Synonyms:	Rrm2b-
Gene:	Rrm2b  Location: Chr15:37924196-37961562 bp, - strand  Genetic Position: Chr15, 15.1 cM
Alliance:	Rrm2btm1Ynak page

Germline Transmission:	Earliest citation of germline transmission: J:84841
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 3.4 kb genomic fragment encompassing exons 3 and 4 was replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected by Northern blot analysis of MEFs derived from homozygous mutant mice. (J:84841)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

12 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rrm2b Mutation:	25 strains or lines available

Original:	J:84841 Kimura T, et al., Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools. Nat Genet. 2003 Aug;34(4):440-5
All:	2 reference(s)