Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ighg1tm1.1Ksho
Name:	immunoglobulin heavy constant gamma 1 (G1m marker); targeted mutation 1.1, Tsuneyasu Kaisho
MGI ID:	MGI:2669501
Synonyms:	IgG1delta m
Gene:	Ighg1  Location: Chr12:113290161-113294143 bp, - strand  Genetic Position: Chr12, 62.1 cM
Alliance:	Ighg1tm1.1Ksho page

Germline Transmission:	Earliest citation of germline transmission: J:39568
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The floxed region containing the exon encoding the transmembrane domain and the stop codon inserted downstream was excised from Igh-4tm1Ksho via in vivo cre mediated recombination. Protein translated from this allele is not expected to localize to the membrane. (J:39568)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ighg1 Mutation:	28 strains or lines available

Original:	J:39568 Kaisho T, et al., The roles of gamma1 heavy chain membrane expression and cytoplasmic tail in IgG1 responses. Science. 1997 Apr 18;276(5311):412-5
All:	1 reference(s)