All Phenotypes Ighg1<tm1.1Ksho> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ighg1^tm1.1Ksho
targeted mutation 1.1, Tsuneyasu Kaisho
MGI:2669501

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ighg1^tm1.1Ksho/Ighg1^tm1.1Ksho	involves: 129P2/OlaHsd * C57BL/6	MGI:2669515
ht2	Ighg1^tm1.1Ksho/Ighg1⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:2669547

Allelic Composition	Ighg1^tm1.1Ksho/Ighg1^tm1.1Ksho
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1^tm1.1Ksho mutation (1 available); any Ighg1 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell physiology ( J:39568 )

• mutants immunized with NP-CG produce strongly impaired primary and secondary IgG1 responses, about two orders of magnitude below the controls

decreased IgG1 level ( J:39568 )

• serum NP-specific IgG1 concentration is reduced by a factor of 71 in mutants immunized with a T cell-dependent antigen, chicken gamma-globulin coupled to 4-hydroxy-3-nitro-phenylacetyl (NP-CG)

hematopoietic system

abnormal B cell physiology ( J:39568 )

• mutants immunized with NP-CG produce strongly impaired primary and secondary IgG1 responses, about two orders of magnitude below the controls

decreased IgG1 level ( J:39568 )

• serum NP-specific IgG1 concentration is reduced by a factor of 71 in mutants immunized with a T cell-dependent antigen, chicken gamma-globulin coupled to 4-hydroxy-3-nitro-phenylacetyl (NP-CG)

Allelic Composition	Ighg1^tm1.1Ksho/Ighg1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1^tm1.1Ksho mutation (1 available); any Ighg1 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell physiology ( J:39568 )

• B cells are unable to mount efficient primary and secondary IgG1 responses

• the impairment is more pronounced than in Ighg1^tm1Ksho mutant mice

decreased IgG1 level ( J:39568 )

• mutants immunized with a T cell-dependent antigen, chicken gamma-globulin (CG) coupled to 4-hydroxy-3-nitro-phenylacetyl (NP), produce less NP-specific IgG1

hematopoietic system

abnormal B cell physiology ( J:39568 )

• B cells are unable to mount efficient primary and secondary IgG1 responses

• the impairment is more pronounced than in Ighg1^tm1Ksho mutant mice

decreased IgG1 level ( J:39568 )

• mutants immunized with a T cell-dependent antigen, chicken gamma-globulin (CG) coupled to 4-hydroxy-3-nitro-phenylacetyl (NP), produce less NP-specific IgG1

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