Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hprt1tm2Detl
Name:	hypoxanthine phosphoribosyltransferase 1; targeted mutation 2, Peter J Detloff
MGI ID:	MGI:2668517
Synonyms:	hprtNLSQ150
Gene:	Hprt1  Location: ChrX:52077014-52110536 bp, + strand  Genetic Position: ChrX, 29.31 cM, cytoband A6
Alliance:	Hprt1tm2Detl page

Germline Transmission:	Earliest citation of germline transmission: J:84451
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Not Applicable) Mutations:    Disruption caused by insertion of vector, Insertion   Mutation details: Exon 3 was disrupted by the insertion of a cassette containing a nuclear localization signal (NLS), myc tag, and 150 CAG repeats encoding 150 glutamine residues. (J:84451)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hprt1 Mutation:	1273 strains or lines available

Original:	J:84451 Jackson WS, et al., Nucleocytoplasmic transport signals affect the age at onset of abnormalities in knock-in mice expressing polyglutamine within an ectopic protein context. Hum Mol Genet. 2003 Jul 1;12(13):1621-9
All:	1 reference(s)