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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hprt1tm2Detl
targeted mutation 2, Peter J Detloff
MGI:2668517
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hprt1tm2Detl/Hprt1tm2Detl involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:2668523
ot2
 		Hprt1tm2Detl/Y involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:2668531


Genotype
MGI:2668523
hm1
Allelic
Composition		 Hprt1tm2Detl/Hprt1tm2Detl
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm2Detl mutation (0 available); any Hprt1 mutation (1274 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:84451 )
• median age of death is 10.5 months

behavior/neurological
abnormal motor capabilities/coordination/movement ( J:84451 )
• mutants lose the ability to escape a tail suspension by climbing onto the observer's hand
decreased locomotor activity ( J:84451 )
• reduced nocturnal activity; mutants roam only 25% of the 2 minute periods during 12 hour dark cycles compared to 50% in wild-type mice
• inactivity in open cage
• age of onset was approximately 1 month earlier than observed in either Hprttm4Detl or Hprttm6Detl mutant mice
seizures ( J:84451 )
• 11 of 17 mutants have seizures at 7-9 months of age

nervous system
seizures ( J:84451 )
• 11 of 17 mutants have seizures at 7-9 months of age
neuronal intranuclear inclusions ( J:84451 )
• neuronal intranuclear inclusions evident by 8-9 months of age; inclusions are larger than in Hprttm4Detl or Hprttm6Detl




Genotype
MGI:2668531
ot2
Allelic
Composition		 Hprt1tm2Detl/Y
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm2Detl mutation (0 available); any Hprt1 mutation (1274 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:84451 )
• median age of death is 10.5 months

behavior/neurological
abnormal motor capabilities/coordination/movement ( J:84451 )
• mutants lose the ability to escape a tail suspension by climbing onto the observer's hand
decreased locomotor activity ( J:84451 )
• reduced nocturnal activity; mutants roam only 25% of the 2 minute periods during 12 hour dark cycles compared to 50% in wild-type mice
• inactivity in open cage
• age of onset is approximately 1 month earlier than observed in either Hprttm4Detl or Hprttm6Detl mutant mice
seizures ( J:84451 )
• 11 of 17 mutants have seizures at 7-9 months of age

nervous system
seizures ( J:84451 )
• 11 of 17 mutants have seizures at 7-9 months of age
neuronal intranuclear inclusions ( J:84451 )
• neuronal intranuclear inclusions evident by 8-9 months of age; inclusions are larger than in Hprttm4Detl or Hprttm6Detl mutants




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory