Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Prkdctm1Fwa
Name:	protein kinase, DNA activated, catalytic polypeptide; targeted mutation 1, Frederick W Alt
MGI ID:	MGI:2667593
Synonyms:	DNA-PKcs-, DNA-PKcsN
Gene:	Prkdc  Location: Chr16:15455730-15660099 bp, + strand  Genetic Position: Chr16, 10.09 cM, cytoband B1
Alliance:	Prkdctm1Fwa page

Germline Transmission:	Earliest citation of germline transmission: J:50221
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Exon 6 was disrupted by the insertion of a neomycin selection cassette. Shortened transcipts were detected in homozygous mutant ES cells by RT-PCR analysis, however neither normal or aberrantly sized protein was detected by Western blot analysis. Assays of cell extracts indicated an ablation of endogenous protein activity. (J:50221)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prkdc Mutation:	408 strains or lines available

Original:	J:50221 Gao Y, et al., A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination. Immunity. 1998 Sep;9(3):367-76
All:	28 reference(s)