|
Allele Symbol Allele Name Allele ID |
Prkdctm1Fwa targeted mutation 1, Frederick W Alt MGI:2667593 |
||||||||||||
| Summary |
2 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 4 to 5-fold reduction in double positive splenocytes
|
| N |
• mice do not exhibit apoptosis in developing nervous system
|
|
• 4 to 5-fold reduction in double positive splenocytes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• total numbers of thymocytes are reduced 100- to 300-fold
|
|
• B cell development is arrested at the B220+CD43+ progenitor B cell stage in which Ig rearrangement processes are initiated
|
|
• mice show impaired V(D)J coding joining but normal signal joining in thymocytes
|
|
• markedly reduced levels of Dbeta2-Jbeta2 joins
• barely detectable levels of Vbeta8-DJbeta2 joins
• however, levels of Ddelta2-Jdelta1 RS joins are normal
|
|
• absence of CD4+CD8+ cells
|
|
• block at an early progenitor stage in which Tcr rearrangement processes are initiated but progression from the double negative to double positive stage is blocked
|
|
• total numbers of thymocytes are reduced 100- to 300-fold
|
|
• B cell development is arrested at the B220+CD43+ progenitor B cell stage in which Ig rearrangement processes are initiated
|
|
• mice show impaired V(D)J coding joining but normal signal joining in thymocytes
|
|
• markedly reduced levels of Dbeta2-Jbeta2 joins
• barely detectable levels of Vbeta8-DJbeta2 joins
• however, levels of Ddelta2-Jdelta1 RS joins are normal
|
|
• absence of CD4+CD8+ cells
|
|
• block at an early progenitor stage in which Tcr rearrangement processes are initiated but progression from the double negative to double positive stage is blocked
|
|
• embryonic fibroblasts, but not ES cells, exhibit increased sensitivity to ionizing radiation
|
|
• total numbers of thymocytes are reduced 100- to 300-fold
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/23/2024 MGI 6.23 |
|
|
|
||
Analysis Tools