Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Sptbn4Gt(ROSABetageo)62Sor
Name:	spectrin beta, non-erythrocytic 4; gene trap 62, Philippe Soriano
MGI ID:	MGI:2657204
Synonyms:	ROSA 62, sigma1sigma6-, Spnb4Gt(ROSABgeo*)62Sor
Gene:	Sptbn4  Location: Chr7:27055808-27147111 bp, - strand  Genetic Position: Chr7, 15.88 cM, cytoband A3
Alliance:	Sptbn4Gt(ROSABetageo)62Sor page

Mutant Cell Line:	ROSA62
Germline Transmission:	Earliest citation of germline transmission: J:77228
Parent Cell Line:	AK7 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Allele Type:    Gene trapped (Null/knockout, Reporter) Mutation:    Insertion of gene trap vector     Vector: ROSABetageo*   Mutation details: A gene trap vector inserted between the exons that encode the spectrin repeat 12 of the protein. Northern blot analysis demonstrated that a fusion transcript was expressed that consisted of the gene sequences and the beta-galactosidase gene of the vector. Western blot analysis on brain lysates of homozygous mice demonstrated that no detectable full length protein was made from this allele. (J:77228) Sequence Tags:  Sequence tag details (1 tag) Tag ID GenBank ID Method Tag Location (trapped strand)* Select FHCRC-GT-ROSA62 CG465913 (MGI Seq Detail) 5' RACE Chr7:27066024-27071428 bp (-) * GRCm39 (strand of gene trap mutagenesis) Selected Tags: download BLAST at NCBI Genome Context:  Genome Browser view of this mutation 31 gene trap insertions have trapped this gene View all gene trap sequence tags in this region

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

2 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sptbn4 Mutation:	122 strains or lines available

Original:	J:77228 Komada M, et al., [Beta]IV-spectrin regulates sodium channel clustering through ankyrin-G at axon initial segments and nodes of Ranvier. J Cell Biol. 2002 Jan 21;156(2):337-48
All:	6 reference(s)