Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sptbn4Gt(ROSABetageo)62Sor mutation
(1 available);
any
Sptbn4 mutation
(122 available)
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behavior/neurological
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• first observable at weaning, continue and worsen with age
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• mice cannot walk at 6-10 months of age
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muscle
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• mice 6-10 months of age exhibit continuous contraction of hind limb skeletal muscle
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sptbn4Gt(ROSABetageo)62Sor mutation
(1 available);
any
Sptbn4 mutation
(122 available)
|
|
|
behavior/neurological
|
|
• first observable at weaning, continue and worsen with age
|
|
|
• mice cannot walk at 6-10 months of age
|
muscle
|
|
• mice 6-10 months of age exhibit continuous contraction of hind limb skeletal muscle
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sptbn4Gt(ROSABetageo)62Sor mutation
(1 available);
any
Sptbn4 mutation
(122 available)
|
|
|
behavior/neurological
|
|
• first observable at weaning, continue and worsen with age
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• mice cannot walk at 6-10 months of age
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• males reproduce very inefficiently when mated with wild-type females
• however, no histological abnormalities are detected and when mating occurs normal litter sizes are produced
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muscle
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• mice 6-10 months of age exhibit continuous contraction of hind limb skeletal muscle
(J:77228)
• at older than 8 months mice often exhibit continuous contraction of hindleg muscle
(J:120916)
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nervous system
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• ankyrin G+ regions of the neurons, but not Purkinje cells, in the cerebral cortex are longer
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• plasma membranes at the Node of Ranvier in the optic nerve are wavy and swollen
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Analysis Tools