Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fn1tm2Feb
Name:	fibronectin 1; targeted mutation 2, Francisco E Baralle
MGI ID:	MGI:2655542
Synonyms:	EDA-, Eda-Fn-, Fn-EIIIA-
Gene:	Fn1  Location: Chr1:71624679-71692359 bp, - strand  Genetic Position: Chr1, 36.05 cM, cytoband C1-C5
Alliance:	Fn1tm2Feb page

Germline Transmission:	Earliest citation of germline transmission: J:84274
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Modified isoform(s)) Mutations:    Insertion, Intragenic deletion   Mutation details: The floxed genomic fragment containing a modified EDA exon was excised from Fn1tm1Feb via in vivo cre mediated recombination in the germline. RNase protection and RT-PCR analysis showed that while transcripts encoding other isoforms were transcribed from the mutant allele, the EDA exon was constituitively excluded in homozygous mutant mice. (J:84274)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fn1 Mutation:	129 strains or lines available

Original:	J:84274 Muro AF, et al., Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan. J Cell Biol. 2003 Jul 7;162(1):149-60
All:	23 reference(s)