Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Aqp5tm1Amn
Name:	aquaporin 5; targeted mutation 1, Anil G Menon
MGI ID:	MGI:2655164
Synonyms:	Aqp5-
Gene:	Aqp5  Location: Chr15:99488909-99492710 bp, + strand  Genetic Position: Chr15, 56.13 cM
Alliance:	Aqp5tm1Amn page

Germline Transmission:	Earliest citation of germline transmission: J:82588
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 600 bp fragment encompassing exon 3 and surrounding intronic sequence was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded extracellular loop E, which contains the conserved Asn-Pro-Ala motif and the merucury-sensitive cysteine at position 182. Neither transcript nor protein was by analyses of salivary glands obtained from homozygous mutant mice. (J:82588)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aqp5 Mutation:	16 strains or lines available

Original:	J:82588 Krane CM, et al., Salivary acinar cells from aquaporin 5-deficient mice have decreased membrane water permeability and altered cell volume regulation. J Biol Chem. 2001 Jun 29;276(26):23413-20
All:	11 reference(s)