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Tg(Mt1-Hgf)18Lmb
Transgene Detail
Summary
Symbol: Tg(Mt1-Hgf)18Lmb
Name: transgene insertion 18, Glenn Merlino
MGI ID: MGI:2447463
Synonyms: MT-HGF/SF, SF/HGF, Tg HFG, Tg(Mt1-HGFSF)18Lmb, Tg(Mt-HGFSF)18Lmb
Transgene: Tg(Mt1-Hgf)18Lmb  Location: unknown  
Alliance: Tg(Mt1-Hgf)18Lmb page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Mt1-Hgf)18Lmb expresses 1 gene
 
Tg(Mt1-Hgf)18Lmb expression driven by 1 gene
 
Mutation details: The transgene consists of a mouse metallothionein 1 promoter, the entire mouse hepatocyte growth factor cDNA sequence, a human growth hormone polyadenylation site, and mouse Mt1 5' and 3' flanking regions. Northern blot analysis showed transgene expression in all adult transgenic tissues examined. ELIZA assay showed overexpression of transgene product in urine and serum samples. (J:34022)
Tumor Data
List all tumor models in MMHCdb carrying Tg(Mt1-Hgf)18Lmb
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Nine founders carrying between 7-27 copies of the transgene were created. Transgenic animals over-expressed the transgene 3-fold to 50-fold. The line 18 transgene, Tg(Mt-HGFSF)18Lmb, is also called MT-HGF/SF.
Phenotypic Similarity to Human Syndrome: Melanoma (J:189221)
References
Original:  J:34022 Takayama H, et al., Scatter factor/hepatocyte growth factor as a regulator of skeletal muscle and neural crest development. Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5866-71
All:  16 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory