Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Del(9Hspb2-Cryab)1Wawr
Name:	deletion, Chr 9, Eric F Wawrousek 1
MGI ID:	MGI:2652177
Synonyms:	alphaB-, alphaB/HSPB2-, alphaBKO-168, Cryab-, Cryab/Hspb2tm1Wawr
Gene:	Del(9Hspb2-Cryab)1Wawr  Location: unknown  Genetic Position: Chr9, Syntenic

Germline Transmission:	Earliest citation of germline transmission: J:72926
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intergenic deletion, Intragenic deletion   Del(9Hspb2-Cryab)1Wawr involves 2 genes/genome features (Hspb2, Cryab) View all   Mutation details: The insertion of a single targeting vector containing neo disrupted both Cryab and Hspb2. All of exons 1 and 2 and a portion of exon 3 were deleted at the Cryab locus. All of exon 1 and a portion of exon 2 were deleted at the Hspb2 locus. Cryab protein was undetected by Western blot analysis of homozgous mutant mice. Northern blot analysis of homozygous mutant heart and skeletal muscle showed an absence of Hspb2 mRNA. (J:72926)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Del(9Hspb2-Cryab)1Wawr Mutation:	0 strains or lines available

Original:	J:72926 Brady JP, et al., AlphaB-crystallin in lens development and muscle integrity: a gene knockout approach. Invest Ophthalmol Vis Sci. 2001 Nov;42(12):2924-34
All:	37 reference(s)