Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Ptger2tm1Sna
Name:	prostaglandin E receptor 2 (subtype EP2); targeted mutation 1, Shuh Narumiya
MGI ID:	MGI:2651880
Synonyms:	EP(2)-, EP2-, Ptger2-
Gene:	Ptger2  Location: Chr14:45225652-45241277 bp, + strand  Genetic Position: Chr14, 22.68 cM
Alliance:	Ptger2tm1Sna page

Germline Transmission:	Earliest citation of germline transmission: J:70534
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The 3' portion of exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected by Northern blot analysis of uterine tissue obtained from homozygous mutant females. (J:57482, J:70534)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

List all tumor models in MMHCdb carrying Ptger2tm1Sna

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptger2 Mutation:	31 strains or lines available

Original:	J:70534 Ushikubi F, et al., Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. Nature. 1998 Sep 17;395(6699):281-4
All:	49 reference(s)