Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Find Mice (IMSR) | Notes | References

Symbol:	Tg(Prnp-tTA)F959Sbp
Name:	transgene insertion F959, Stanley B Prusiner
MGI ID:	MGI:2445786
Synonyms:	Tg(Prnp-tTA/F959), Tg(Prnp-tTA)FV
Transgene:	Tg(Prnp-tTA)F959Sbp  Location: unknown
Alliance:	Tg(Prnp-tTA)F959Sbp page

Strain of Origin:

FVB.129S7(B6)-Prnptm1Cwe/J

Transgene Type:    Transgenic (Transactivator) Mutation:    Insertion   Mutation details: A tet transactivator gene under the control of a mouse Prnp promoter was used for the transgene. The mouse Prnp promoter targets transgene expression to the brain. High levels of transgene expression was observed in the cortex and hippocampus, and lower levels were observed in thalamic, hypothalamic, and brainstem regions via mRNA in situ hybridization. (J:50359)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:50359 Tremblay P, et al., Doxycycline control of prion protein transgene expression modulates prion disease in mice. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12580-5
All:	12 reference(s)