Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Asic3tm1Pig
Name:	acid-sensing ion channel 3; targeted mutation 1, Andreas Zimmer
MGI ID:	MGI:2451051
Synonyms:	ASIC3-
Gene:	Asic3  Location: Chr5:24618449-24622836 bp, + strand  Genetic Position: Chr5, 11.72 cM
Alliance:	Asic3tm1Pig page

Germline Transmission:	Earliest citation of germline transmission: J:81785
Parent Cell Line:	MPI-II (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of exons 2-11 with a lacZ-neo cassette via homologous recombination. The targeted mutation results in deletion of the second transmembrane domain as well as most of the extracellular domain. Absence of gene expression in homozygous mutant animals was confirmed by Northern blot analysis of dorsal root ganglion cells using a probe to exon 1. (J:81785)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Asic3 Mutation:	29 strains or lines available

Original:	J:81785 Chen CC, et al., A role for ASIC3 in the modulation of high-intensity pain stimuli. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8992-7
All:	14 reference(s)