Phenotypes associated with this allele

• Allele Symbol: Asic3^tm1Pig
• Allele Name: targeted mutation 1, Andreas Zimmer
• Allele ID: MGI:2451051
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Asic3^tm1Pig/Asic3^tm1Pig	involves: 129/Sv * CD-1	MGI:2451052

Genotype
MGI:2451052

hm1

• Allelic Composition: Asic3^tm1Pig/Asic3^tm1Pig
• Genetic Background: involves: 129/Sv * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:81785 )

N • homozygotes displayed normal responses in the von Frey fiber test when low-intensity stimuli were applied

N • following s.c. carrageenan or capsaicin, mutant and wild-type animals showed similar levels of thermal hyperalgesia (Hargreave's test) and mechanical allodynia (von Frey fiber test)

hyperresponsive to tactile stimuli ( J:81785 )

• homozygotes displayed significantly enhanced pain responses when a high-intensity mechanical stimulus (tail pinch) was applied

decreased chemical nociceptive threshold ( J:81785 )

• in the acetic acid-induced writhing test, homozygotes screamed while they were injected, had more writhing bouts, and displayed an earlier onset of pain responses relative to wild-type

• these effects were observed at high- (0.6%) but not at low-acid concentrations

abnormal mechanical nociception ( J:81785 )

• homozygotes were more sensitive to tail pressure than wild-type mice

decreased thermal nociceptive threshold ( J:81785 )

• homozygotes displayed normal responses in the tail-flick test, but had significantly lower response latencies in the hot-plate test at high- but not low-temperature settings

nervous system

nervous system phenotype ( J:81785 )

N • homozygotes were viable, fertile and healthy, and displayed normal expression levels of other members of the same gene family in the spinal cord, brainstem, and brain

N • mutants showed no gross developmental changes in the dorsal root ganglia