Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Wnt3tm2Amc
Name:	wingless-type MMTV integration site family, member 3; targeted mutation 2, Andrew P McMahon
MGI ID:	MGI:2450903
Synonyms:	Wnt3c
Gene:	Wnt3  Location: Chr11:103664976-103708783 bp, + strand  Genetic Position: Chr11, 67.5 cM
Alliance:	Wnt3tm2Amc page

Germline Transmission:	Earliest citation of germline transmission: J:81795
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A 5' loxP site was introduced into intron 2 and a 3' loxP site was introduced into intron 4 via homologous recombination. An frt-flanked neo cassette was also introduced into the 3' site for positive selection. (J:81795)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	52 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

List all tumor models in MMHCdb carrying Wnt3tm2Amc

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wnt3 Mutation:	25 strains or lines available

Original:	J:81795 Barrow JR, et al., Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge. Genes Dev. 2003 Feb 1;17(3):394-409
All:	9 reference(s)