Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hhiptm1Amc
Name:	Hedgehog-interacting protein; targeted mutation 1, Andrew P McMahon
MGI ID:	MGI:2450891
Synonyms:	Hip1-
Gene:	Hhip  Location: Chr8:80692480-80784635 bp, - strand  Genetic Position: Chr8, 37.95 cM, cytoband C3
Alliance:	Hhiptm1Amc page

Germline Transmission:	Earliest citation of germline transmission: J:81798
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: The endogenous locus was disrupted by the insertion of cassette containing lacZ and PGK-neo genes. The start codon and downstream sequences were deleted from exon 1. The expression pattern of beta-galactosidase was similar to that of the endogenous gene. (J:81798)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	40 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hhip Mutation:	43 strains or lines available

Original:	J:81798 Chuang PT, et al., Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung. Genes Dev. 2003 Feb 1;17(3):342-7
All:	15 reference(s)