Mfn1tm1Dcc
Targeted Allele Detail
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Symbol: |
Mfn1tm1Dcc |
Name: |
mitofusin 1; targeted mutation 1, David C Chan |
MGI ID: |
MGI:2450304 |
Synonyms: |
Mfn1 |
Gene: |
Mfn1 Location: Chr3:32583614-32633388 bp, + strand Genetic Position: Chr3, 15.75 cM, cytoband B
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Alliance: |
Mfn1tm1Dcc page
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Germline Transmission: |
Earliest citation of germline transmission:
J:81438
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129S/SvEv
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exon 3 of the endogenous allele was disrupted by the insertion of a neomycin selection cassette via homologous recombination. The deleted region encoded the G1 and G2 motifs of the GTPase domain. The insertion introduced a translational stop codon into the 5' region of exon 3. Protein was undetected by Western blot analysis of homozygous mutant embryos.
(J:81438)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Mfn1 Mutation: |
44 strains or lines available
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Original: |
J:81438 Chen H, et al., Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J Cell Biol. 2003 Jan 21;160(2):189-200 |
All: |
12 reference(s) |
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