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Rettm1Jmi
Targeted Allele Detail
Summary
Symbol: Rettm1Jmi
Name: ret proto-oncogene; targeted mutation 1, Jeffrey Milbrandt
MGI ID: MGI:2449909
Synonyms: RetGFP, RetTGM
Gene: Ret  Location: Chr6:118128706-118174679 bp, - strand  Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
Alliance: Rettm1Jmi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:71881
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsThe gene was disrupted by insertion of an EGFP-derived cassette and a floxed neo cassette into exon 1 via homologous recombination. The floxed neo cassette was removed by mating mutant animals to cre deleter strain TgN(ACTB-cre)2Mrt. Immunohistochemical analysis of homozygous mutant newborns confirmed the absence of gene expression in spinal motorneurons. (J:71881)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 30 assay results
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ret Mutation:  53 strains or lines available
Notes
Homozygous mutant animals lacked kidneys and enteric neurons and died shortly after birth.
References
Original:  J:71881 Enomoto H, et al., RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons. Development. 2001 Oct;128(20):3963-74
All:  35 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory