Tg(Cd4-SKP1A)1Ingh
Transgene Detail
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| Symbol: |
Tg(Cd4-SKP1A)1Ingh |
| Name: |
transgene insertion 1, Giorgio Inghirami |
| MGI ID: |
MGI:2447880 |
| Synonyms: |
Tg Skp1 |
| Transgene: |
Tg(Cd4-SKP1A)1Ingh Location: unknown
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| Alliance: |
Tg(Cd4-SKP1A)1Ingh page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Cd4-SKP1A)1Ingh expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
SKP1 (6500) |
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Mutation details: The transgene consists of a mouse Cd4 promoter and a constitutively expressed flag-tagged human SKP1A sequence. Mouse Cd4 regulatory sequences were used to drive transgene expression in T lymphocytes. The Cd4 regulatory region includes the minimal enhancer, minimal promoter, 70 bp of exon 1, and part of intron 1. The Cd4 promoter lacks the silencer region and is transcriptionally active in both single- and double-positive T cells. Transgene expression was confirmed by Western blot analysis of thymocyte extracts from transgenic animals.
(J:80320)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:80320 Piva R, et al., In vivo interference with Skp1 function leads to genetic instability and neoplastic transformation. Mol Cell Biol. 2002 Dec;22(23):8375-87 |
| All: |
1 reference(s) |
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Analysis Tools
