Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hpxtm1Altr
Name:	hemopexin; targeted mutation 1, Fiorella Altruda
MGI ID:	MGI:2447193
Synonyms:	Hx-
Gene:	Hpx  Location: Chr7:105240818-105249323 bp, - strand  Genetic Position: Chr7, 55.91 cM, cytoband F1
Alliance:	Hpxtm1Altr page

Germline Transmission:	Earliest citation of germline transmission: J:58821
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: The gene was disrupted by insertion of a lacZ-neo cassette into the ATG start site of exon 1. Absence of gene expression in homozygous animals was confirmed by Northern blot analysis of total liver RNA. X-gal staining showed expression of lacZ in liver sections from mutant animals. (J:58821)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hpx Mutation:	30 strains or lines available

Original:	J:58821 Tolosano E, et al., Defective recovery and severe renal damage after acute hemolysis in hemopexin-deficient mice. Blood. 1999 Dec 1;94(11):3906-14
All:	16 reference(s)