Phenotypes associated with this allele

• Allele Symbol: Hpx^tm1Altr
• Allele Name: targeted mutation 1, Fiorella Altruda
• Allele ID: MGI:2447193
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hpx^tm1Altr/Hpx^tm1Altr	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	MGI:3609565
cx2	Hp^tm1Skl/Hp^tm1Skl Hpx^tm1Altr/Hpx^tm1Altr	involves: 129/Sv * 129P2/OlaHsd * C57BL/6J	MGI:3609566

Genotype
MGI:3609565

hm1

• Allelic Composition: Hpx^tm1Altr/Hpx^tm1Altr
• Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating haptoglobin level ( J:58821 )

• haptoglobin levels remain elevated at least 7 days after induced acute hemolysis

increased kidney iron level ( J:58821 )

• heavier than normal deposition in the proximal tubules of the kidney after induced acute hemolysis

hemoglobinuria ( J:58821 )

• persists at least 7 days after induced acute hemolysis

renal/urinary system

increased kidney iron level ( J:58821 )

• heavier than normal deposition in the proximal tubules of the kidney after induced acute hemolysis

hemoglobinuria ( J:58821 )

• persists at least 7 days after induced acute hemolysis

abnormal proximal convoluted tubule morphology ( J:58821 )

• heavier than normal deposition of hemoglobin in the proximal tubules after induced acute hemolysis

abnormal kidney physiology ( J:58821 )

• kidney damage after induced acute hemolysis

• increased lipid peroxidation in kidneys after induced acute hemolysis as measured by malonaldehyde levels

hematopoietic system

hematopoietic system phenotype ( J:58821 )

N • cell numbers for all blood cell lineages are similar to controls in untreated mice

Genotype
MGI:3609566

cx2

• Allelic Composition: Hp^tm1Skl/Hp^tm1Skl; Hpx^tm1Altr/Hpx^tm1Altr
• Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:80539 )

• reduced susceptibility to lethal hemolytic stress resulting from administration of phenylhydrazine

homeostasis/metabolism

abnormal blood homeostasis ( J:80539 )

• recovery of blood chemistry parameters after induced acute hemolysis, almost complete by 7 days

abnormal circulating protein level ( J:80539 )

• heme oxygenase levels not elevated as much as normal as a result of induced acute hemolysis

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:80539 )

• reduced susceptibility to lethal hemolytic stress resulting from administration of phenylhydrazine

liver/biliary system

liver inflammation ( J:80539 )

• increased kupffer cell accumulation of hemoglobin 1 day after induced acute hemolysis

• pronounced inflammation after 7 days

• splenectomy also leads to liver inflammation

immune system

enlarged spleen ( J:80539 )

• after induced acute hemolysis

increased spleen red pulp amount ( J:80539 )

• enlarged spleen largely due to increased red pulp, accumulation of red blood cells

liver inflammation ( J:80539 )

• increased kupffer cell accumulation of hemoglobin 1 day after induced acute hemolysis

• pronounced inflammation after 7 days

• splenectomy also leads to liver inflammation

hematopoietic system

enlarged spleen ( J:80539 )

• after induced acute hemolysis

increased spleen red pulp amount ( J:80539 )

• enlarged spleen largely due to increased red pulp, accumulation of red blood cells

growth/size/body

enlarged spleen ( J:80539 )

• after induced acute hemolysis