Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Acrtm1Wen
Name:	acrosin prepropeptide; targeted mutation 1, Wolfgang Engel
MGI ID:	MGI:2429958
Synonyms:	Acr-
Gene:	Acr  Location: Chr15:89452549-89458790 bp, + strand  Genetic Position: Chr15, 44.96 cM, cytoband E-F
Alliance:	Acrtm1Wen page

Germline Transmission:	Earliest citation of germline transmission: J:38658
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Exon 2 was disrupted by the insertion of a neomycin selection cassette. Aberrant transcripts were detected by Northern blot and RT-PCR analyses of mutant mice. The use of various cDNA fragments and sequence analysis indicated that the mutant transcripts lacked portions of exon 2 and contained neomycin sequence. Southern blot analysis confirmed that the aberrant splicing was not a result of incorrect recombination. No protein was detected by immunostaining of sperm obtained from homozygous mutant mice. (J:38658)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acr Mutation:	46 strains or lines available

Original:	J:38658 Adham IM, et al., Spermatozoa lacking acrosin protein show delayed fertilization. Mol Reprod Dev. 1997 Mar;46(3):370-6
All:	4 reference(s)