Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bcantm1Ref
Name:	brevican; targeted mutation 1, Reinhard Fassler
MGI ID:	MGI:2388924
Synonyms:	BC-
Gene:	Bcan  Location: Chr3:87894838-87907537 bp, - strand  Genetic Position: Chr3, 38.78 cM
Alliance:	Bcantm1Ref page

Germline Transmission:	Earliest citation of germline transmission: J:79605
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: The entire coding region of the endogenous gene was replaced with a promoterless lacZ and a neomycin selection cassette. The absence of transcript and protein was determined via Northern and Western blot analysis of homozygous mutant mice. (J:79605)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bcan Mutation:	46 strains or lines available

Original:	J:79605 Brakebusch C, et al., Brevican-deficient mice display impaired hippocampal CA1 long-term potentiation but show no obvious deficits in learning and memory. Mol Cell Biol. 2002 Nov;22(21):7417-27
All:	10 reference(s)