Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcantm1Ref mutation
(0 available);
any
Bcan mutation
(46 available)
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behavior/neurological
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N |
• homozygotes exhibit normal spatial learning (water-maze test)
• homozygotes show normal motor coordination (rota-rod test)
• consistent with grossly normal hippocampal functions, acquisition and performance levels are only slightly, but insignificantly, reduced in the two-way active-avoidance paradigm
• other behavioral paradigms indicate normal gross sensory functions, reflexes, home cage activity, and food consumption
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Allelic
Composition |
Bcantm1Ref/Bcantm1Ref
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Genetic
Background |
either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcantm1Ref mutation
(0 available);
any
Bcan mutation
(46 available)
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nervous system
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N |
• homozygotes exhibit a normal brain anatomy; however, an up-regulation of chondroitin sulfate proteoglycan-3 (neurocan) protein is detected in the mutant forebrain
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• the hippocampal CA1 region shows normal synapse distribution, frequency, and morphology
• basal properties and short-term plasticity of excitatory and inhibitory synapses to the pyramidal cells in the hippocampal CA1 region appear normal
• perineuronal nets are present around hippocampal nonpyramidal neurons in both wild-type and homozygous null mice; in mutants, however, the nets appear fuzzier and are less pronounced and less concentrated close to the plasma membrane
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• homozygotes show significant defects in the maintenance of hippocampal LTP in brain slices, although the initial fEPSP slope is normal
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Analysis Tools