Tg(Ela1-CCKBR)1Mduf
Transgene Detail
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| Symbol: |
Tg(Ela1-CCKBR)1Mduf |
| Name: |
transgene insertion 1, Marlene Dufresne |
| MGI ID: |
MGI:2384537 |
| Synonyms: |
ElasCCKB |
| Transgene: |
Tg(Ela1-CCKBR)1Mduf Location: unknown
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| Alliance: |
Tg(Ela1-CCKBR)1Mduf page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Ela1-CCKBR)1Mduf expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
CCKBR (887) |
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Mutation details: A human CCKBR cDNA sequence driven by the rat elastase 1 promoter was used for the transgene. The -500 to +8 region of the rat elastase 1 promoter specifically targets expression of the transgene to pancreatic acinar cells. RT-PCR analysis of mRNA from pancreas, brain, and other tissues confirmed that the human gene is expressed only in the pancreas of transgenic animals. Western blot of pancreatic plasma membranes using antibodies directed against the third extracellular loop of human CCKBR demonstrated the presence of human protein in the pancreas of transgenic animals.
(J:50987)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:50987 Saillan-Barreau C, et al., Transgenic CCK-B/gastrin receptor mediates murine exocrine pancreatic secretion. Gastroenterology. 1998 Oct;115(4):988-96 |
| All: |
5 reference(s) |
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Analysis Tools
