Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Slatm1Weis
Name:	src-like adaptor; targeted mutation 1, Arthur Weiss
MGI ID:	MGI:2387691
Synonyms:	SLAP-
Gene:	Sla  Location: Chr15:66652668-66703678 bp, - strand  Genetic Position: Chr15, 29.3 cM
Alliance:	Slatm1Weis page

Germline Transmission:	Earliest citation of germline transmission: J:71804
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of part of the promoter region and sequences encoding the first 21 amino acids with a neomycin resistance cassette. Northern blot using a probe to the C-terminal region of the gene and RT-PCR analysis of homozygous animals confirmed inactivation of the gene. Sequence analysis of a weak RT-PCR product revealed an alternatively spliced truncated transcript. (J:71804)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sla Mutation:	20 strains or lines available

Original:	J:71804 Sosinowski T, et al., The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection. Immunity. 2001 Sep;15(3):457-66
All:	14 reference(s)