Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tnfsf13btm1Msc
Name:	tumor necrosis factor (ligand) superfamily, member 13b; targeted mutation 1, Martin L Scott
MGI ID:	MGI:2387426
Synonyms:	BAFF-, BLyS-
Gene:	Tnfsf13b  Location: Chr8:10056229-10086000 bp, + strand  Genetic Position: Chr8, 4.55 cM
Alliance:	Tnfsf13btm1Msc page

Germline Transmission:	Earliest citation of germline transmission: J:71681
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 1-2 (732 bp of the gene) encoding the first 134 residues were replaced with a human CD2 reporter gene fused to a neomycin resistance cassette. Northern blot analysis of spleen RNA using probes to the deleted region did not detect gene transcript in homozygous mutant animals. (J:71681)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnfsf13b Mutation:	28 strains or lines available

Original:	J:71681 Schiemann B, et al., An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science. 2001 Sep 14;293(5537):2111-4
All:	45 reference(s)