Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tcf12tm1Zhu
Name:	transcription factor 12; targeted mutation 1, Yuan Zhuang
MGI ID:	MGI:2387400
Synonyms:	HEB-, HEBko
Gene:	Tcf12  Location: Chr9:71751534-72019611 bp, - strand  Genetic Position: Chr9, 39.85 cM
Alliance:	Tcf12tm1Zhu page

Germline Transmission:	Earliest citation of germline transmission: J:43324
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The insertion of a neomycin selection cassette deleted sequence encoding the 3' portion of the basic helix-loop-helix (bHLH) domain. The disruption of the bHLH precludes dimerization, thereby preventing the potential for DNA binding activity. (J:43324)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcf12 Mutation:	74 strains or lines available

Original:	J:43324 Zhuang Y, et al., B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB. Mol Cell Biol. 1996 Jun;16(6):2898-905
All:	15 reference(s)