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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tcf12tm1Zhu
targeted mutation 1, Yuan Zhuang
MGI:2387400
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tcf12tm1Zhu/Tcf12tm1Zhu involves: 129/Sv * C57BL/6 MGI:3040598
hm2
 		Tcf12tm1Zhu/Tcf12tm1Zhu involves: 129S7/SvEvBrd MGI:3709890
hm3
 		Tcf12tm1Zhu/Tcf12tm1Zhu involves: 129S7/SvEvBrd * C57BL/6J MGI:3803024
ht4
 		Tcf12tm1Zhu/Tcf12tm2Zhu involves: 129S7/SvEvBrd MGI:3709889
cn5
 		Tcf12tm1Zhu/Tcf12+
Tcf3tm4Zhu/Tcf3tm4Zhu
Tg(Lck-cre)#Zhu/0 		involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL MGI:3774553
cx6
 		Tcf12tm1Zhu/Tcf12+
Tcf4tm1Zhu/Tcf4+ 		involves: 129P2/OlaHsd * 129S7/SvEvBrd MGI:3040601
cx7
 		Tcf12tm1Zhu/Tcf12+
Tcf3tm1Wein/Tcf3+ 		involves: 129S4/SvJaeSor MGI:3040599


Genotype
MGI:3040598
hm1
Allelic
Composition		 Tcf12tm1Zhu/Tcf12tm1Zhu
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf12tm1Zhu mutation (0 available); any Tcf12 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:43324 )
• most homozygotes died within two weeks of birth

hematopoietic system
decreased pro-B cell number ( J:43324 )
• 50% reduction in the number of pro-B cells in homozygote

immune system
decreased pro-B cell number ( J:43324 )
• 50% reduction in the number of pro-B cells in homozygote




Genotype
MGI:3709890
hm2
Allelic
Composition		 Tcf12tm1Zhu/Tcf12tm1Zhu
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf12tm1Zhu mutation (0 available); any Tcf12 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte number ( J:120411 )
• thymocyte number is reduced 10-fold relative to controls in 2-3 week old mice
arrested T cell differentiation ( J:120411 )
• block in development at the immature single positive (ISP) stage

hematopoietic system
decreased thymocyte number ( J:120411 )
• thymocyte number is reduced 10-fold relative to controls in 2-3 week old mice
arrested T cell differentiation ( J:120411 )
• block in development at the immature single positive (ISP) stage

nervous system
nervous system phenotype ( J:125313 )
N
• the pontine nucleus develops normally

endocrine/exocrine glands
decreased thymocyte number ( J:120411 )
• thymocyte number is reduced 10-fold relative to controls in 2-3 week old mice




Genotype
MGI:3803024
hm3
Allelic
Composition		 Tcf12tm1Zhu/Tcf12tm1Zhu
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf12tm1Zhu mutation (0 available); any Tcf12 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
thymus hypoplasia ( J:136143 )
• thymi cultured for 7 days exhibit reduced total cell numbers compared to wild-type thymi
increased double-negative T cell number ( J:136143 )
• most pronounced in DN3 cells

hematopoietic system
thymus hypoplasia ( J:136143 )
• thymi cultured for 7 days exhibit reduced total cell numbers compared to wild-type thymi
increased double-negative T cell number ( J:136143 )
• most pronounced in DN3 cells

endocrine/exocrine glands
thymus hypoplasia ( J:136143 )
• thymi cultured for 7 days exhibit reduced total cell numbers compared to wild-type thymi




Genotype
MGI:3709889
ht4
Allelic
Composition		 Tcf12tm1Zhu/Tcf12tm2Zhu
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf12tm1Zhu mutation (0 available); any Tcf12 mutation (74 available)
Tcf12tm2Zhu mutation (0 available); any Tcf12 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
arrested T cell differentiation ( J:120411 )
• T cell development can proceed to the ISP stage but not to the single positive (SP) stage

immune system
arrested T cell differentiation ( J:120411 )
• T cell development can proceed to the ISP stage but not to the single positive (SP) stage




Genotype
MGI:3774553
cn5
Allelic
Composition		 Tcf12tm1Zhu/Tcf12+
Tcf3tm4Zhu/Tcf3tm4Zhu
Tg(Lck-cre)#Zhu/0
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf12tm1Zhu mutation (0 available); any Tcf12 mutation (74 available)
Tcf3tm4Zhu mutation (2 available); any Tcf3 mutation (39 available)
Tg(Lck-cre)#Zhu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell differentiation ( J:75746 )
• there is a developmental block between the double negative and immature single positive stages of T cell development
increased double-negative T cell number ( J:75746 )
• 2-week old mice exhibit a dramatic accumulation of double negative T cells
increased single-positive T cell number ( J:75746 )
• 2-week old mice exhibit a dramatic accumulation of immature single positive T cells

immune system
abnormal T cell differentiation ( J:75746 )
• there is a developmental block between the double negative and immature single positive stages of T cell development
increased double-negative T cell number ( J:75746 )
• 2-week old mice exhibit a dramatic accumulation of double negative T cells
increased single-positive T cell number ( J:75746 )
• 2-week old mice exhibit a dramatic accumulation of immature single positive T cells




Genotype
MGI:3040601
cx6
Allelic
Composition		 Tcf12tm1Zhu/Tcf12+
Tcf4tm1Zhu/Tcf4+
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf12tm1Zhu mutation (0 available); any Tcf12 mutation (74 available)
Tcf4tm1Zhu mutation (0 available); any Tcf4 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:43324 )
• most homozygotes died within two weeks of birth

growth/size/body
postnatal growth retardation ( J:43324 )
• evident after birth

hematopoietic system
decreased pro-B cell number ( J:43324 )
• 50% reduction in the number of pro-B cells

immune system
decreased pro-B cell number ( J:43324 )
• 50% reduction in the number of pro-B cells

nervous system
nervous system phenotype ( J:125313 )
N
• the pontine nucleus develops normally




Genotype
MGI:3040599
cx7
Allelic
Composition		 Tcf12tm1Zhu/Tcf12+
Tcf3tm1Wein/Tcf3+
Genetic
Background		 involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf12tm1Zhu mutation (0 available); any Tcf12 mutation (74 available)
Tcf3tm1Wein mutation (0 available); any Tcf3 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:43324 )
• most homozygotes died within two weeks of birth

growth/size/body
postnatal growth retardation ( J:43324 )
• evident after birth

hematopoietic system
decreased pro-B cell number ( J:43324 )
• 70% reduction in the number of pro-B cells

immune system
decreased pro-B cell number ( J:43324 )
• 70% reduction in the number of pro-B cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory