Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | Notes | References

Symbol:	Tcf4tm1Zhu
Name:	transcription factor 4; targeted mutation 1, Yuan Zhuang
MGI ID:	MGI:2387399
Synonyms:	E2-2-, Tcf4-
Gene:	Tcf4  Location: Chr18:69476500-69821038 bp, + strand  Genetic Position: Chr18, 43.23 cM, cytoband E2
Alliance:	Tcf4tm1Zhu page

Germline Transmission:	Earliest citation of germline transmission: J:43324
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The insertion of a neomycin selection cassette deleted sequence encoding the carboxy terminal, including a portion of the basic helix-loop-helix (bHLH) domain. The disruption of the bHLH precludes dimerization, thereby preventing the potential for DNA binding activity. (J:43324)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tcf4 Mutation:	56 strains or lines available

Original:	J:43324 Zhuang Y, et al., B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB. Mol Cell Biol. 1996 Jun;16(6):2898-905
All:	14 reference(s)