All Phenotypes Tcf4<tm1Zhu> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tcf4^tm1Zhu/Tcf4^tm1Zhu	involves: 129P2/OlaHsd	MGI:3776857
hm2	Tcf4^tm1Zhu/Tcf4^tm1Zhu	involves: 129P2/OlaHsd * C57BL/6	MGI:3040597
ht3	Tcf4^tm1Zhu/Tcf4⁺	involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6J	MGI:6479882
cn4	Tcf4^tm1Hmb/Tcf4^tm1Zhu Tg(Kit-cre)143Hmb/?	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3719236
cx5	Tcf4^tm1Zhu/Tcf4⁺ Tcf3^tm1Zhu/Tcf3⁺	involves: 129P2/OlaHsd	MGI:3776854
cx6	Atoh1^tm2Hzo/Atoh1⁺ Tcf4^tm1Zhu/Tcf4⁺	involves: 129P2/OlaHsd	MGI:3776856
cx7	Tcf4^tm1Zhu/Tcf4⁺ Tcf3^tm1Wein/Tcf3⁺	involves: 129P2/OlaHsd	MGI:3040600
cx8	Tcf12^tm1Zhu/Tcf12⁺ Tcf4^tm1Zhu/Tcf4⁺	involves: 129P2/OlaHsd * 129S7/SvEvBrd	MGI:3040601

Allelic Composition	Tcf4^tm1Zhu/Tcf4^tm1Zhu
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf4^tm1Zhu mutation (0 available); any Tcf4 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:125313 )

• mice die within the first 24 hours of birth but no embryonic lethality is observed as previously noted

nervous system

abnormal brain development ( J:125313 )

• the pontine nuclei is disrupted

Allelic Composition	Tcf4^tm1Zhu/Tcf4^tm1Zhu
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf4^tm1Zhu mutation (0 available); any Tcf4 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:43324 )

• homozygotes born with low frequency and died within one week of birth

hematopoietic system

decreased pro-B cell number ( J:43324 )

• 50% reduction in the number of pro-B cells in homozygotes

immune system

decreased pro-B cell number ( J:43324 )

• 50% reduction in the number of pro-B cells in homozygotes

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired contextual conditioning behavior ( J:239016 )

• mice show reduced freezing in the contextual fear conditioning tests

• mice treated subchronically with suberoylanilide hydroxamic acid show rescue of memory-associated freezing in the contextual and cued tests

impaired cued conditioning behavior ( J:239016 )

• mice show reduced freezing in the cued fear conditioning test

• mice treated subchronically with suberoylanilide hydroxamic acid show rescue of memory-associated freezing in the contextual and cued tests

impaired spatial learning ( J:239016 )

• in the Morris water maze, mice fail to show selectivity for the target quadrant, spending less time there than wild-type mice and crossing the platform zone fewer times

abnormal long-term spatial reference memory ( J:239016 )

• mice have a deficit in the 24 hour object location memory indicating impaired spatial memory

increased grooming behavior ( J:239016 )

• mice groom themselves more than wild-type mice

increased startle reflex ( J:239016 )

• mice exhibit enhanced startle reflex to unexpected 120 dB sound bursts

impaired balance ( J:239016 )

• mice exhibit asymmetry in their motor control and an imbalance that favors their left size

• however, mice show no differences on the rotating rod or in walking across a horizontal ladder

decreased grip strength ( J:239016 )

• mice show weaker hindlimb, but not forelimb, grip strength

abnormal gait ( J:239016 )

• mice favor their front left paw while ambulating across a catwalk

• dynamic weight bearing analysis indicates that mice place more weight on their front left paw than their right paw

increased locomotor activity ( J:239016 )

• mice show increased activity in the open field and in the elevated plus maze, where mice show an increase in overall arm entrances

• however, mice do not show an increase in anxiety in the open field or elevated plus maze

social withdrawal ( J:239016 )

• mice prefer social isolation over interaction with a novel mouse in the three-chamber social test

decreased vocalization ( J:239016 )

• pups have reduced ultrasonic vocalization when removed from the nest, which remains low until the phenotype converges with normal behavior or wild-type controls around P7

• P3 pups have weaker calls

• P3 pups have less frequent ultrasonic distress calls and at lower volumes

nervous system

enhanced long-term potentiation ( J:239016 )

• mice exhibit enhanced Schaffer collateral long-term potentiation when activated with theta burst stimulation

• hippocampal CA1 area treated with the HDAC inhibitor Trichostatin A before theta burst stimulation normalizes the LTP

decreased prepulse inhibition ( J:239016 )

• mice have deficits in prepulse inhibition

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Pitt-Hopkins syndrome		DOID:0060488	OMIM:610954	J:239016

Allelic Composition	Tcf4^tm1Hmb/Tcf4^tm1Zhu Tg(Kit-cre)143Hmb/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf4^tm1Hmb mutation (0 available); any Tcf4 mutation (55 available)
Tcf4^tm1Zhu mutation (0 available); any Tcf4 mutation (55 available)
Tg(Kit-cre)143Hmb mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased thymocyte number ( J:65236 )

• fewer thymocytes with the Tcf4^tm1Hmb allele are detected

abnormal B cell differentiation ( J:65236 )

• fewer B220-CD3- B cells with the Tcf4^tm1Hmb allele are detected

decreased double-positive T cell number ( J:65236 )

• fewer immature CD4+CD8+ T cells with the Tcf4^tm1Hmb allele are detected

spleen hypoplasia ( J:65236 )

• fewer splenocytes with the Tcf4^tm1Hmb allele are detected

immune system

decreased thymocyte number ( J:65236 )

• fewer thymocytes with the Tcf4^tm1Hmb allele are detected

abnormal B cell differentiation ( J:65236 )

• fewer B220-CD3- B cells with the Tcf4^tm1Hmb allele are detected

decreased double-positive T cell number ( J:65236 )

• fewer immature CD4+CD8+ T cells with the Tcf4^tm1Hmb allele are detected

spleen hypoplasia ( J:65236 )

• fewer splenocytes with the Tcf4^tm1Hmb allele are detected

endocrine/exocrine glands

decreased thymocyte number ( J:65236 )

• fewer thymocytes with the Tcf4^tm1Hmb allele are detected

Allelic Composition	Tcf4^tm1Zhu/Tcf4⁺ Tcf3^tm1Zhu/Tcf3⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3^tm1Zhu mutation (0 available); any Tcf3 mutation (39 available)
Tcf4^tm1Zhu mutation (0 available); any Tcf4 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:125313 )

N	• the pontine nucleus develops normally

Allelic Composition	Atoh1^tm2Hzo/Atoh1⁺ Tcf4^tm1Zhu/Tcf4⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh1^tm2Hzo mutation (1 available); any Atoh1 mutation (36 available)
Tcf4^tm1Zhu mutation (0 available); any Tcf4 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuronal migration ( J:125313 )

• mice die within the first 24 hours of birth but no embryonic lethality is observed as previously noted

abnormal brain development ( J:125313 )

• the pontine nuclei is disrupted

cellular

abnormal neuronal migration ( J:125313 )

• mice die within the first 24 hours of birth but no embryonic lethality is observed as previously noted

Allelic Composition	Tcf4^tm1Zhu/Tcf4⁺ Tcf3^tm1Wein/Tcf3⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3^tm1Wein mutation (0 available); any Tcf3 mutation (39 available)
Tcf4^tm1Zhu mutation (0 available); any Tcf4 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:43324 )

• most homozygotes died within two weeks of birth

growth/size/body

postnatal growth retardation ( J:43324 )

• evident after birth

hematopoietic system

decreased pro-B cell number ( J:43324 )

• 70% reduction in the number of pro-B cells

immune system

decreased pro-B cell number ( J:43324 )

• 70% reduction in the number of pro-B cells

Allelic Composition	Tcf12^tm1Zhu/Tcf12⁺ Tcf4^tm1Zhu/Tcf4⁺
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf12^tm1Zhu mutation (0 available); any Tcf12 mutation (74 available)
Tcf4^tm1Zhu mutation (0 available); any Tcf4 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:43324 )

• most homozygotes died within two weeks of birth

growth/size/body

postnatal growth retardation ( J:43324 )

• evident after birth

hematopoietic system

decreased pro-B cell number ( J:43324 )

• 50% reduction in the number of pro-B cells

immune system

decreased pro-B cell number ( J:43324 )

• 50% reduction in the number of pro-B cells

nervous system

nervous system phenotype ( J:125313 )

N	• the pontine nucleus develops normally

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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