Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Usp18tm1Dez
Name:	ubiquitin specific peptidase 18; targeted mutation 1, Dong-Er Zhang
MGI ID:	MGI:2387336
Synonyms:	UBP43-, Usp18LacZ, Usp18tm1Dzh
Gene:	Usp18  Location: Chr6:121222865-121247876 bp, + strand  Genetic Position: Chr6, 57.17 cM, cytoband F
Alliance:	Usp18tm1Dez page

Germline Transmission:	Earliest citation of germline transmission: J:78821
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2-4, which contain the translation initiation codon and Cys domain, were replaced with a neo-lacZ cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was verified by Western blot analysis of LPS-stimulated thymus glands. (J:78821)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

List all tumor models in MMHCdb carrying Usp18tm1Dez

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Usp18 Mutation:	25 strains or lines available

Original:	J:78821 Ritchie KJ, et al., Dysregulation of protein modification by ISG15 results in brain cell injury. Genes Dev. 2002 Sep 1;16(17):2207-12
All:	26 reference(s)