Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lnpeptm1Ske
Name:	leucyl/cystinyl aminopeptidase; targeted mutation 1, Susanna R Keller
MGI ID:	MGI:2387151
Synonyms:	IRAP-
Gene:	Lnpep  Location: Chr17:17747985-17846303 bp, - strand  Genetic Position: Chr17, 9.77 cM
Alliance:	Lnpeptm1Ske page

Germline Transmission:	Earliest citation of germline transmission: J:76570
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2 through 6 and their intervening introns were replaced with a neomycin resistance gene. The deleted region included sequence encoding the cytoplasmic tail involved in subcellular localization and regulation, the transmembrane domain, and the zinc binding site that is essential for catalytic activity. Western blot analysis indicated an absence of normal protein in homozygous mutant mice. (J:76570)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lnpep Mutation:	99 strains or lines available

Original:	J:76570 Keller SR, et al., Mice Deficient in the Insulin-regulated Membrane Aminopeptidase Show Substantial Decreases in Glucose Transporter GLUT4 Levels but Maintain Normal Glucose Homeostasis. J Biol Chem. 2002 May 17;277(20):17677-86
All:	10 reference(s)