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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lnpeptm1Ske
targeted mutation 1, Susanna R Keller
MGI:2387151
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lnpeptm1Ske/Lnpeptm1Ske B6.129S-Lnpeptm1Ske MGI:6116663
hm2
Lnpeptm1Ske/Lnpeptm1Ske involves: 129S/SvEv * Black Swiss MGI:3582359


Genotype
MGI:6116663
hm1
Allelic
Composition
Lnpeptm1Ske/Lnpeptm1Ske
Genetic
Background
B6.129S-Lnpeptm1Ske
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lnpeptm1Ske mutation (1 available); any Lnpep mutation (99 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• in mice fed a high-fat diet
• in mice fed a high-fat diet
• with reduced numbers of cells containing lipid droplets in ependymal fat pads
• in the abdominal fat of mice fed a high-fat diet

homeostasis/metabolism
N
• mice exhibit normal basal levels of glucose, insulin, cholesterol, triglycerides or free fatty acids
• mice exhibit normal adaptive thermogenesis
• in mice fed a high-fat diet
• in mice fed a high-fat diet
• in mice fed a high-fat diet
• mild hyperthermia in rectal temperature with a 4-fold increase in UCP-1 (a key regulator of thermogenesis) levels in brown adipose tissue
• in mice fed a high-fat diet
• in mice fed a high-fat diet
• in mice fed a high-fat diet but not as much as in wild-type mice

growth/size/body
N
• mice exhibit normal fat weight and body weight
• in mice fed a high-fat diet




Genotype
MGI:3582359
hm2
Allelic
Composition
Lnpeptm1Ske/Lnpeptm1Ske
Genetic
Background
involves: 129S/SvEv * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lnpeptm1Ske mutation (1 available); any Lnpep mutation (99 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• insulin stimulated uptake of glucose by muscle was decreased
• basal uptake of glucose by adipocytes was reduced 30% in males and 45% in females
• ability of insulin to lower blood glucose was modestly impaired

cardiovascular system
• hearts of males about 20% larger than controls

growth/size/body
• hearts of males about 20% larger than controls





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last database update
05/21/2024
MGI 6.23
The Jackson Laboratory