Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Il6sttm2Thir
Name:	interleukin 6 signal transducer; targeted mutation 2, Toshio Hirano
MGI ID:	MGI:2386993
Synonyms:	gp130FXXQ
Gene:	Il6st  Location: Chr13:112600604-112643394 bp, + strand  Genetic Position: Chr13, 63.73 cM
Alliance:	Il6sttm2Thir page

Germline Transmission:	Earliest citation of germline transmission: J:59922
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Humanized sequence) Mutation:    Nucleotide substitutions   Mutation details: A human Il6st cDNA fragment carrying tyrosine to phenylalanine substitutions at amino acids 767, 814, 905, and 915, was used to replaced the corresponding region of the mouse gene. A downstream neomycin resistance cassette was also inserted for positive selection. (J:59922)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il6st Mutation:	80 strains or lines available

Original:	J:59922 Ohtani T, et al., Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. Immunity. 2000 Jan;12(1):95-105
All:	7 reference(s)