Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6sttm2Thir mutation
(1 available);
any
Il6st mutation
(80 available)
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skeleton
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• there is no suppressive effect of IL-6 family cytokines on the proliferation of osteoblasts isolated from E18.5 calvariae
• the induction of ALP activity by the IL-6 family cytokines IL-6, IL-11, and OSM is markedly suppressed in these mice
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cellular
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• there is no suppressive effect of IL-6 family cytokines on the proliferation of osteoblasts isolated from E18.5 calvariae
• the induction of ALP activity by the IL-6 family cytokines IL-6, IL-11, and OSM is markedly suppressed in these mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6sttm2Thir mutation
(1 available);
any
Il6st mutation
(80 available)
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mortality/aging
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• pups die within one day of birth
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immune system
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• in lethally irradiated wild-type mice receiving mutant fetal liver cells, there is a 45% reduction in the number of B-1a B cells found in the peritoneum
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• the primary and secondary antigen-specific IgG1 response to immunization with T cell dependent antigen is reduced in lethally irradiated mice receiving mutant fetal liver cells
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• in lethally irradiated wild-type mice receiving mutant fetal liver cells, IgG2a levels are significantly lower than controls
• the primary antigen-specific IgG2a response to immunization with T cell dependent antigen is also reduced in these chimeric mice
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• in lethally irradiated wild-type mice receiving mutant fetal liver cells, IgG2b levels are significantly lower than controls
• the primary and secondary antigen-specific IgG2b response to immunization with T cell dependent antigen is also reduced in these chimeric mice
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• the secondary antigen-specific IgM response to immunization with T cell dependent antigen is increased in lethally irradiated mice receiving mutant fetal liver cells
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• bone marrow derived dendritic cells treated with IL-6 have a greater reduction in MHC-II surface expression than in controls
• dendritic cells isolated from lymph nodes have a 40% reduction in surface expression of MHC-II
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• in lethally irradiated mice receiving mutant fetal liver cells, IFN-gamma secretion is 0.6-fold of that in wild-type mice
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hematopoietic system
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• there is a slight but significant reduction in CFU-M isolated from the bone marrow when macrophage-colony stimulating factor is used as a stimulus
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• in lethally irradiated wild-type mice receiving mutant fetal liver cells, there is a 45% reduction in the number of B-1a B cells found in the peritoneum
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• the primary and secondary antigen-specific IgG1 response to immunization with T cell dependent antigen is reduced in lethally irradiated mice receiving mutant fetal liver cells
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• in lethally irradiated wild-type mice receiving mutant fetal liver cells, IgG2a levels are significantly lower than controls
• the primary antigen-specific IgG2a response to immunization with T cell dependent antigen is also reduced in these chimeric mice
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• in lethally irradiated wild-type mice receiving mutant fetal liver cells, IgG2b levels are significantly lower than controls
• the primary and secondary antigen-specific IgG2b response to immunization with T cell dependent antigen is also reduced in these chimeric mice
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• the secondary antigen-specific IgM response to immunization with T cell dependent antigen is increased in lethally irradiated mice receiving mutant fetal liver cells
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Analysis Tools