Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(Cd4-cre)1Cwi
Name:	transgene insertion 1, Christopher B Wilson
MGI ID:	MGI:2386448
Synonyms:	CD4cre, CD4Cre, CD4-Cre, CD4-Cre+, CD4CRE, CD4-creTg, CD4p-Cre, Tg(CD4-cre)1Cw1
Transgene:	Tg(Cd4-cre)1Cwi  Location: unknown  Genetic Position: Chr3, Syntenic
Alliance:	Tg(Cd4-cre)1Cwi page

Strain of Origin:

(C57BL/6 x DBA/2)F2

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(Cd4-cre)1Cwi expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Cd4 (MGI:88335)   Mutation details: Cre recombinase is expressed under the control of mouse Cd4 regulatory elements. The Cd4 enhancer, promoter and silencer collectively drive expression at sequential stages specifically of CD4+ T cell development. The integration site of the transgene construct is at position 60335693-60341285 (qD) of chromosome 3 and the insert contains at least 15 complete sequential copies of the transgenic construct. (J:73127, J:302838)

Activity:	Tissue activity of this recombinase allele
Driver:	Cd4 (mouse) Summary of all recombinase alleles driven by Cd4. Comparative matrix view of recombinase activities Alliance mouse Cd4 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

8 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 10 strains available      Cell Lines: 0 lines available

Original:	J:73127 Lee PP, et al., A critical role for dnmt1 and DNA methylation in T cell development, function, and survival. Immunity. 2001 Nov;15(5):763-74
All:	1455 reference(s)