Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Epas1tm1Fong
Name:	endothelial PAS domain protein 1; targeted mutation 1, Guo-Hua Fong
MGI ID:	MGI:2386334
Synonyms:	EPAS-1
Gene:	Epas1  Location: Chr17:87061292-87140838 bp, + strand  Genetic Position: Chr17, 56.9 cM
Alliance:	Epas1tm1Fong page

Germline Transmission:	Earliest citation of germline transmission: J:63415
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: The majority of exon 2, which encodes the basic helix-loop-helix domain, was replaced with a cassette containing both IRES-lacZ and neo genes. Transcript was undetected by RT-PCR analyses of homozygous mutant embryos. Weak expression of beta-galactosidase, putatively due to the inefficiency of the IRES, showed the pattern of expression to recapitulate that of the endogenous gene. (J:63415)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

24 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Epas1 Mutation:	64 strains or lines available

Original:	J:63415 Peng J, et al., The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8386-91
All:	5 reference(s)