Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cd37tm1Hor
Name:	CD37 antigen; targeted mutation 1, Ivan Horak
MGI ID:	MGI:2386160
Synonyms:	CD37-
Gene:	Cd37  Location: Chr7:44883056-44888539 bp, - strand  Genetic Position: Chr7, 29.2 cM
Alliance:	Cd37tm1Hor page

Germline Transmission:	Earliest citation of germline transmission: J:63315
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Part of exon 3 and all of exon 4 were replaced with a PGK-neo cassette in the reverse orientation via homologous recombination. The gene targeting event results in deletion of part of the second transmembrane domain and the entire third transmembrane domain. Absence of gene expression in homozygous mutant animals was verified by Northern blot analysis of spleen mRNA using a Cd37 cDNA probe. (J:63315)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd37 Mutation:	28 strains or lines available

Original:	J:63315 Knobeloch KP, et al., Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions. Mol Cell Biol. 2000 Aug;20(15):5363-9
All:	12 reference(s)