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Kcna5tm1(Kcna1)Lndn
Targeted Allele Detail
Summary
Symbol: Kcna5tm1(Kcna1)Lndn
Name: potassium voltage-gated channel, shaker-related subfamily, member 5; targeted mutation 1, Barry London
MGI ID: MGI:2384510
Synonyms: SWAP
Gene: Kcna5  Location: Chr6:126509514-126512375 bp, - strand  Genetic Position: Chr6, 61.35 cM
Alliance: Kcna5tm1(Kcna1)Lndn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78122
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA construct containing rat Kcna1 sequence appended with a hemagglutinin tag (HA) and neo was incorporated at the enodogenous locus via homologous recombination. The rat sequence was inserted such that it would replace the Kcna5 coding sequence and be expressed by the Kcna5 promoter. Northern blot analysis confirmed the absence of Kcna5, while the presence of the rat Kcna1 was detected by RT-PCR analysis. HA epitope directed antibodies showed a 62 kDa protein in the heart tissue obtained from mutant mice, but not in brain tissue. (J:78122)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcna5 Mutation:  34 strains or lines available
References
Original:  J:78122 London B, et al., Targeted replacement of KV1.5 in the mouse leads to loss of the 4-aminopyridine-sensitive component of I(K,slow) and resistance to drug-induced qt prolongation. Circ Res. 2001 May 11;88(9):940-6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory